[Treatment of traditional Chinese medicine for idiopathic male infertility]

Hinyokika Kiyo. 2004 Aug;50(8):545-8.
[Article in Japanese]


Several Chinese herbal medicines have been used to treat patients with idiopathic male infertility and have been reported to improve semen quality. The clinical efficacy of these medicines was reviewed. The therapeutic effect of Hochu-ekki-to based on the pretreatment traditional diagnosis (Sho) was examined. Three months after the administration of Hochu-ekki-to, the semen count and motility significantly increased in comparison with pretreatment values. When the patients were classified into 3 categories based on "Sho", Hochu-ekki-to was effective in semen motility in patients with vacuity pattern (Kyo-Sho). Seminal plasma soluble Fas (sFas) levels before and three months after the administration of drug were analyzed. Seminal plasma sFas level elevated significantly after the administration of Hochu-ekki-to. After the administration of Hochu-ekki-to, seminal plasma sFas levels significantly correlated with sperm concentration. To make the best use of traditional medicine, it is important to give medication according to the traditional diagnosis (Sho).

Publication types

  • Review

MeSH terms

  • Biomarkers / analysis
  • Drugs, Chinese Herbal / therapeutic use*
  • Humans
  • Infertility, Male / diagnosis
  • Infertility, Male / drug therapy*
  • Infertility, Male / physiopathology
  • Male
  • Medicine, Chinese Traditional
  • Phytotherapy*
  • Semen / chemistry
  • Sperm Count
  • fas Receptor / analysis


  • Biomarkers
  • Drugs, Chinese Herbal
  • bu-zhong-yi-qi-tang
  • fas Receptor
  • saiko-ka-ryukotsu-borei-to