Enhanced prevalence of ankyloglossia with maternal cocaine use

Cleft Palate Craniofac J. 1992 Jan;29(1):72-6. doi: 10.1597/1545-1569_1992_029_0072_epoawm_2.3.co_2.


A series of 500 term neonates was examined in a well-baby nursery, 68 of whom tested positive for maternal cocaine use. From logistic multiple regression equations, weight and crown-heel length were significantly smaller in the maternal cocaine-use subset of this case-control study. Partial ankyloglossia, with a prevalence of 4.4 percent in the overall series, was significantly more common in males than in females (6.0% versus 2.3%), while race (black or white) had no influence on trait frequency. Controlling for race and sex, ankyloglossia was 3.5 times more likely to occur in the drug-use series, perhaps as a function of diminished mitotic rates.

MeSH terms

  • Abnormalities, Drug-Induced / epidemiology*
  • Birth Weight / drug effects
  • Black or African American
  • Body Height / drug effects
  • Case-Control Studies
  • Cocaine* / adverse effects
  • Crack Cocaine* / adverse effects
  • Female
  • Humans
  • Infant, Newborn
  • Logistic Models
  • Male
  • Maternal-Fetal Exchange*
  • Pregnancy
  • Prevalence
  • Regression Analysis
  • Risk Factors
  • Sex Factors
  • Substance-Related Disorders / complications*
  • Tongue / abnormalities*
  • White People


  • Crack Cocaine
  • Cocaine