Fatal staphylococcal sepsis in Crohn's disease after infliximab

Inflamm Bowel Dis. 2004 Sep;10(5):655-6. doi: 10.1097/00054725-200409000-00024.

Abstract

We report a case of a 40-year-old woman who had received infliximab for perianal Crohn's disease. After six infusions of infliximab, the patient developed staphylococcal pneumonia resulting in fatal adult respiratory distress syndrome. The case is discussed in the context of the toxicity profile of infliximab.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Antibodies, Monoclonal / adverse effects*
  • Crohn Disease / complications*
  • Crohn Disease / drug therapy*
  • Fatal Outcome
  • Female
  • Gastrointestinal Agents / adverse effects*
  • Humans
  • Infliximab
  • Pneumonia, Bacterial / chemically induced*
  • Rectal Fistula / etiology
  • Rectal Fistula / pathology
  • Respiratory Distress Syndrome / chemically induced
  • Sepsis / chemically induced*
  • Staphylococcal Infections / chemically induced*
  • Tumor Necrosis Factor-alpha

Substances

  • Antibodies, Monoclonal
  • Gastrointestinal Agents
  • Tumor Necrosis Factor-alpha
  • Infliximab