Subcellular domain-restricted GABAergic innervation in primary visual cortex in the absence of sensory and thalamic inputs

Nat Neurosci. 2004 Nov;7(11):1184-6. doi: 10.1038/nn1334. Epub 2004 Oct 10.


Distinct classes of GABAergic synapses target restricted subcellular domains, thereby differentially regulating the input, integration and output of principal neurons, but the underlying mechanism for such synapse segregation is unclear. Here we show that the distributions of two major classes of GABAergic synapses along the perisomatic and dendritic domains of pyramidal neurons were indistinguishable between primary visual cortex in vivo and cortical organotypic cultures. Therefore, subcellular synapse targeting is independent of thalamic input and probably involves molecular labels and experience-independent forms of activity.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Afferent Pathways / physiology
  • Analysis of Variance
  • Animals
  • Cell Size
  • Cell Surface Extensions / physiology*
  • Chi-Square Distribution
  • Interneurons / physiology
  • Mice
  • Mice, Transgenic
  • Models, Neurological
  • Organ Culture Techniques
  • Parvalbumins / genetics
  • Pyramidal Cells / cytology
  • Pyramidal Cells / physiology*
  • Somatostatin / genetics
  • Synapses / classification
  • Synapses / physiology*
  • Thalamus / physiology*
  • Visual Cortex / cytology*
  • Visual Cortex / physiology
  • gamma-Aminobutyric Acid / metabolism*


  • Parvalbumins
  • Somatostatin
  • gamma-Aminobutyric Acid