Synthesis and potent antimicrobial activity of some novel 4-(5, 6-dichloro-1H-benzimidazol-2-yl)-N-substituted benzamides

Seçkin Ozden; Hacer Karataş; Sulhiye Yildiz; Hakan Göker

doi:10.1002/ardp.200400884

Synthesis and potent antimicrobial activity of some novel 4-(5, 6-dichloro-1H-benzimidazol-2-yl)-N-substituted benzamides

Arch Pharm (Weinheim). 2004 Oct;337(10):556-62. doi: 10.1002/ardp.200400884.

Authors

Seçkin Ozden¹, Hacer Karataş, Sulhiye Yildiz, Hakan Göker

Affiliation

¹ Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, 06100 Tandogan, Ankara, Turkey.

PMID: 15476288
DOI: 10.1002/ardp.200400884

Abstract

A series of 4-(5, 6-dichloro-1H-benzimidazol-2-yl)-N-substituted benzamides were synthesized and evaluated for antibacterial and antifungal activities against Staphylococcus aureus, methicillin-resistant S. aureus (MRSA), methicillin-resistant S. epidermis (MRSE), Enterococcus faecalis, Escherichia coli and Candida albicans. Certain compounds inhibit bacterial growth with low MIC values (microg/mL). Among them, compounds 10 and 11 exhibited the greatest antibacterial activity with MIC values of 3.12 microg/mL against S. aureus, MRSA and MRSE.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / chemical synthesis*
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology
Antifungal Agents / chemical synthesis*
Antifungal Agents / chemistry
Antifungal Agents / pharmacology
Benzamides / chemical synthesis*
Benzamides / chemistry
Benzamides / pharmacology
Candida albicans / drug effects
Enterococcus faecalis / drug effects
Escherichia coli / drug effects
Methicillin Resistance
Microbial Sensitivity Tests
Staphylococcus aureus / drug effects
Staphylococcus epidermidis / drug effects
Structure-Activity Relationship

Substances

Anti-Bacterial Agents
Antifungal Agents
Benzamides