Screening of wood damaging fungi and macrofungi for inhibitors of pancreatic lipase

Phytother Res. 2004 Sep;18(9):758-62. doi: 10.1002/ptr.1548.

Abstract

A total of 120 methanol and dichloromethane extracts, from 60 species of wood-damaging fungi and 50 methanol/water extracts from macrofungi were screened for inhibition of pancreatic lipase using the chromogenic substrate p-nitrophenylpalmitate. Of the extracts screened, those from Laetiporus sulphureus, Tylopilus felleus and Hygrocybe conica exhibited the highest lipase inhibitory activities of 83% +/- 5%, 96% +/- 3% and 97% +/- 5%, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Enzyme Inhibitors / administration & dosage
  • Enzyme Inhibitors / pharmacology*
  • Enzyme Inhibitors / therapeutic use
  • Fungi*
  • Humans
  • Lipase / antagonists & inhibitors*
  • Pancreas / drug effects
  • Pancreas / enzymology*
  • Phytotherapy*
  • Plant Extracts / administration & dosage
  • Plant Extracts / pharmacology*
  • Plant Extracts / therapeutic use
  • Wood

Substances

  • Enzyme Inhibitors
  • Plant Extracts
  • Lipase