Direct generation of Ti-enolate of alpha-CF3 ketone: theoretical study and high-yielding and diastereoselective Aldol reaction

Yoshimitsu Itoh; Masahiro Yamanaka; Koichi Mikami

doi:10.1021/ja046518a

Direct generation of Ti-enolate of alpha-CF3 ketone: theoretical study and high-yielding and diastereoselective Aldol reaction

J Am Chem Soc. 2004 Oct 20;126(41):13174-5. doi: 10.1021/ja046518a.

Authors

Yoshimitsu Itoh¹, Masahiro Yamanaka, Koichi Mikami

Affiliation

¹ Department of Applied Chemistry, Tokyo Institute of Technology, Tokyo 152-8552, Japan.

PMID: 15479042
DOI: 10.1021/ja046518a

Abstract

Success in the direct generation of the Ti-enolate of alpha-CF3 ketone and its aldol reaction is reported. The importance of Ti-F interaction during the course of the reaction is also reported.

MeSH terms

Aldehydes / chemistry*
Hydrocarbons, Fluorinated / chemical synthesis*
Ketones / chemical synthesis*
Models, Molecular
Molecular Conformation
Organometallic Compounds / chemistry
Stereoisomerism
Thermodynamics
Titanium / chemistry

Substances

Aldehydes
Hydrocarbons, Fluorinated
Ketones
Organometallic Compounds
Titanium