Hyperlipoproteinemia impairs endothelium-dependent vasodilation

Physiol Res. 2004;53(5):471-80.

Abstract

Atherogenic lipoproteins can cause endothelial dysfunction in the initial stage of atherogenesis. In our study we examined 134 patients with defined hyperlipoproteinemia (non-HDL cholesterol>4.1 mmol/l or triglycerides>2.5 mmol/l or taking any of lipid lowering drugs)--94 men and 40 women. The subgroup of controls of comparable age contained 54 normolipidemic individuals--30 men and 24 women. Patients with hyperlipoproteinemia revealed significantly lower ability of endothelium-dependent flow-mediated vasodilation (EDV) measured on brachial artery (4.13+/-3.07 vs. 5.41+/-3.82 %; p=0.032) and higher carotid intima media thickness than normolipidemic controls (0.68+/-0.22 vs. 0.58+/-0.15 mm; p=0.005). In regression analysis, EDV correlated significantly with plasma concentrations of oxLDL (p<0.05) HDL-cholesterol (p<0.05), Apo A1 (p<0.05), ATI (p<0.01) and non-HDL cholesterol (p<0.05). Patients with hyperlipoproteinemia showed higher plasma levels of oxLDL (65.77+/-9.54 vs. 56.49+/-7.80 U/l; p=0.015), malondialdehyde (0.89+/-0.09 vs. 0.73+/-0.08 micromol/l; p=0.010) and nitrites/nitrates (20.42+/-4.88 vs. 16.37+/-4.44 micromol/l; p=0.018) indicating possible higher long-term oxidative stress in these patients.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Distribution
  • Aged
  • Arteriosclerosis / blood*
  • Arteriosclerosis / epidemiology*
  • Arteriosclerosis / pathology
  • Causality
  • Cohort Studies
  • Comorbidity
  • Czech Republic / epidemiology
  • Dilatation, Pathologic / blood
  • Dilatation, Pathologic / epidemiology
  • Dilatation, Pathologic / pathology
  • Endothelium, Vascular / metabolism*
  • Endothelium, Vascular / pathology
  • Female
  • Humans
  • Hyperlipoproteinemias / blood*
  • Hyperlipoproteinemias / epidemiology*
  • Hyperlipoproteinemias / pathology
  • Incidence
  • Lipoproteins / blood*
  • Male
  • Middle Aged
  • Risk Assessment
  • Risk Factors*
  • Sex Distribution
  • Vasodilation

Substances

  • Lipoproteins