Spatial positioning; a new dimension in genome function

Cell. 2004 Oct 15;119(2):153-6. doi: 10.1016/j.cell.2004.09.035.


The eukaryotic cell nucleus is a heterogeneous organelle. Chromosomes are nonrandomly positioned within the nuclear space, and individual gene loci experience distinct local environments due to the presence of chromatin domains and subnuclear compartments. Recent observations have highlighted the important yet still largely mysterious role of spatial positioning in genome activity and stability.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Nucleus / metabolism*
  • Chromosome Positioning*
  • Chromosomes / metabolism*
  • Gene Expression Regulation
  • Genome
  • Genomic Instability
  • Humans