Control of influenza virus infection by immunity to conserved viral features

Expert Rev Anti Infect Ther. 2003 Dec;1(4):627-38. doi: 10.1586/14787210.1.4.627.

Abstract

Influenza has circulated among humans for centuries and kills more people than many newly emerging diseases. The present methods for control of influenza are not adequate, especially for dealing with a pandemic. In the face of a rapidly spreading outbreak, a race to isolate the virus and prepare a vaccine would probably not succeed in time to avoid great losses. Thus, additional anti-infection strategies are needed. Broad cross-protection against widely divergent influenza A subtypes is readily achieved in animals by several means of immunization. How does cross-protection work in animals, and can we apply what we have learned about it to induce broad cross-protection in humans?

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Antibodies, Viral / immunology
  • B-Lymphocytes / immunology
  • Disease Models, Animal
  • Humans
  • Influenza Vaccines / immunology
  • Influenza, Human / immunology*
  • Influenza, Human / prevention & control
  • T-Lymphocytes / immunology
  • Vaccination
  • Vaccines, DNA / immunology

Substances

  • Antibodies, Viral
  • Influenza Vaccines
  • Vaccines, DNA