Control of influenza virus infection by immunity to conserved viral features

Expert Rev Anti Infect Ther. 2003 Dec;1(4):627-38. doi: 10.1586/14787210.1.4.627.


Influenza has circulated among humans for centuries and kills more people than many newly emerging diseases. The present methods for control of influenza are not adequate, especially for dealing with a pandemic. In the face of a rapidly spreading outbreak, a race to isolate the virus and prepare a vaccine would probably not succeed in time to avoid great losses. Thus, additional anti-infection strategies are needed. Broad cross-protection against widely divergent influenza A subtypes is readily achieved in animals by several means of immunization. How does cross-protection work in animals, and can we apply what we have learned about it to induce broad cross-protection in humans?

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Antibodies, Viral / immunology
  • B-Lymphocytes / immunology
  • Disease Models, Animal
  • Humans
  • Influenza Vaccines / immunology
  • Influenza, Human / immunology*
  • Influenza, Human / prevention & control
  • T-Lymphocytes / immunology
  • Vaccination
  • Vaccines, DNA / immunology


  • Antibodies, Viral
  • Influenza Vaccines
  • Vaccines, DNA