Novel missense polymorphism in the regulator of G-protein signaling 10 gene: analysis of association with schizophrenia

Psychiatry Clin Neurosci. 2004 Oct;58(5):579-81. doi: 10.1111/j.1440-1819.2004.01303.x.


Dysfunction of neuronal signal transduction via G-protein has previously been speculated to be involved in the pathophysiology of schizophrenia. Regulator of G-protein signaling (RGS) is a protein that acts as a GTPase-activator for Galpha protein. A total of 33 Japanese patients with schizophrenia were screened for mutations in the coding region of the RGS10 gene, and a novel missense polymorphism (Val38Met) in the RGS domain was detected. A case-control study did not reveal a significant association between this polymorphism and schizophrenia. The results do not provide evidence that the RGS10 gene is involved in biological vulnerability to schizophrenia.

MeSH terms

  • Adult
  • Aged
  • Alleles
  • Amino Acid Substitution / genetics
  • Case-Control Studies
  • Chromosomes, Human, Pair 10
  • Female
  • Gene Frequency / genetics
  • Genetic Predisposition to Disease / genetics
  • Genetic Testing
  • Genotype
  • Humans
  • Japan
  • Male
  • Middle Aged
  • Mutation, Missense / genetics*
  • Open Reading Frames / genetics
  • Polymorphism, Genetic / genetics*
  • RGS Proteins / genetics*
  • Risk Factors
  • Schizophrenia / diagnosis
  • Schizophrenia / genetics*
  • Schizophrenic Psychology*


  • RGS Proteins
  • RGS10 protein, human