A pilot study of the relationship between selective serotonin reuptake inhibitors and in vitro fertilization outcome

Fertil Steril. 2004 Oct;82(4):968-9. doi: 10.1016/j.fertnstert.2004.02.139.


In a retrospective chart review study women taking selective serotonin reuptake inhibitors antidepressants were compared with a matched comparison group to determine whether there were any differences in IVF outcome-related variables. There were no significant differences between the groups in peak E(2), number of oocytes retrieved, number of oocytes fertilized, percentage of 8-cell or blastocysts developed, day of transfer, or initial hCG values; however, 40% of women taking selective serotonin reuptake inhibitors had ongoing pregnancies compared to 51% of women not taking selective serotonin reuptake inhibitors.

MeSH terms

  • Embryonic Development / physiology
  • Estradiol / blood
  • Female
  • Fertilization in Vitro*
  • Humans
  • Male
  • Oocytes / growth & development
  • Pilot Projects
  • Pregnancy
  • Pregnancy Rate
  • Retrospective Studies
  • Serotonin Uptake Inhibitors / therapeutic use*
  • Treatment Outcome


  • Serotonin Uptake Inhibitors
  • Estradiol