Synaptic computation

Nature. 2004 Oct 14;431(7010):796-803. doi: 10.1038/nature03010.


Neurons are often considered to be the computational engines of the brain, with synapses acting solely as conveyers of information. But the diverse types of synaptic plasticity and the range of timescales over which they operate suggest that synapses have a more active role in information processing. Long-term changes in the transmission properties of synapses provide a physiological substrate for learning and memory, whereas short-term changes support a variety of computations. By expressing several forms of synaptic plasticity, a single neuron can convey an array of different signals to the neural circuit in which it operates.

Publication types

  • Review

MeSH terms

  • Animals
  • Neuronal Plasticity / physiology*
  • Neurons / cytology
  • Neurons / physiology
  • Sound Localization / physiology
  • Synapses / physiology*
  • Synaptic Transmission / physiology