Association of obesity with inflammation in chronic kidney disease: a cross-sectional study

J Ren Nutr. 2004 Oct;14(4):201-7.


Objective: As adipose tissue releases inflammatory cytokines, obesity is associated with elevated C-reactive protein (CRP) levels in the general population. We examined the cross-sectional association of body mass index (BMI) with CRP in patients with chronic kidney disease (CKD).

Design: Cross-sectional study.

Setting and participants: Ninety-four CKD patients with varying levels of renal function seen at the University of Utah outpatient renal clinic were studied.

Methods: Data on demographics (age, gender, race), comorbidity (diabetes mellitus, hypertension, myocardial infarction/angina, cerebrovascular disease, peripheral vascular disease, and smoking) and anthropometry (height and weight) were obtained by patient interview and chart reviews. High-sensitivity CRP was measured by the N-latex assay on a BN II nephelometer.

Main outcome measure: Risk factors of high CRP.

Results: In a multivariable logistic regression model, when compared with patients with a BMI < 25, the odds of CRP > 3.0 mg/L were 2.5-fold (95% CI, 1.02 to 5.99) higher in patients with BMI > or = 30. In a stepwise multiple linear regression model, BMI (regression coefficient [beta] = 0.06; 95% CI, 0.03 to 0.1; P < .01), serum creatinine (beta = 0.16; 95% CI, 0.04 to 0.3; P = .01) and age (beta = 0.01; 95% CI, -0.001 to 0.03; P = .05) were significantly associated with log transformed CRP.

Conclusion: These data suggest that as in the general population, in CKD patients, obesity, a traditional risk factor for atherosclerosis, is associated with inflammation, a novel risk factor for atherosclerosis.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adult
  • Aged
  • Atherosclerosis / complications
  • Body Mass Index
  • C-Reactive Protein / analysis*
  • Chronic Disease
  • Creatinine / blood
  • Cross-Sectional Studies
  • Diabetes Complications
  • Female
  • Humans
  • Hypertension / complications
  • Inflammation / complications*
  • Kidney Diseases / complications*
  • Kidney Failure, Chronic / etiology
  • Logistic Models
  • Male
  • Middle Aged
  • Obesity / complications*
  • Risk Factors
  • Serum Albumin / analysis
  • Smoking / epidemiology


  • Serum Albumin
  • C-Reactive Protein
  • Creatinine