Life and death decisions: secondary complexes and lipid rafts in TNF receptor family signal transduction

Immunity. 2004 Oct;21(4):461-5. doi: 10.1016/j.immuni.2004.10.001.


Signaling by receptors in the TNF receptor (TNFR) superfamily mediate biological outcomes ranging from inflammation to apoptosis and other forms of programmed cell death. How receptor signaling mediates these divergent responses is just beginning to be understood. Here, we discuss how receptor submembrane localization and the formation of alternate signaling complexes can alter the fate of cells stimulated through TNFRs with a death domain, also known as "death receptors."

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Death / physiology*
  • Humans
  • Membrane Microdomains / physiology*
  • Receptors, Tumor Necrosis Factor / physiology*
  • Signal Transduction / physiology*


  • Receptors, Tumor Necrosis Factor