Interleukin-17 Family Members and Inflammation

Immunity. 2004 Oct;21(4):467-76. doi: 10.1016/j.immuni.2004.08.018.

Abstract

IL-17A was cloned more than 10 years ago and six IL-17 family members (IL-17A-F) have subsequently been described. IL-17A is largely produced by activated memory T lymphocytes but stimulates innate immunity and host defense. IL-17A and IL-17F both mobilize neutrophils partly through granulopoeisis and CXC chemokine induction, as well as increased survival locally. IL-17A and IL-17F production by T lymphocytes is regulated by IL-23 independent of T cell receptor activation. Increasing evidence shows that IL-17 family members play an active role in inflammatory diseases, autoimmune diseases, and cancer. This places IL-17 family members and their receptors as potential targets for future pharmacotherapy.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Humans
  • Inflammation / immunology*
  • Interleukin-17 / physiology*
  • Models, Immunological*
  • Receptors, Interleukin / immunology
  • Receptors, Interleukin-17
  • Signal Transduction / immunology*
  • T-Lymphocytes / immunology

Substances

  • IL17RA protein, human
  • Interleukin-17
  • Receptors, Interleukin
  • Receptors, Interleukin-17