A prospective study linked both alcohol and tobacco to Dupuytren's disease

J Clin Epidemiol. 2004 Aug;57(8):858-63. doi: 10.1016/j.jclinepi.2003.11.015.


Objective: To address the role of alcohol intake and tobacco smoking and the combination of the two on subsequent risk of Dupuytren's disease.

Study design and setting: Cohort study of 7,254 subjects enrolled in the Copenhagen City Heart Study (1981-1983). Both self-reported information on lifestyle and objective measures at the baseline examination were linked to presence of Dupuytren's disease at a subsequent examination (1991-1994) using multivariate logistic regression analysis.

Results: A total of 772 subjects had signs of Dupuytren's disease at follow-up. After adjustment for age, sex, educational level, diabetes, and either alcohol or tobacco consumption, respectively, odds ratios for having the disease increased in a dose-dependent manner with increasing levels of alcohol or tobacco intake; however, there was no statistical interaction between heavy smoking and heavy drinking.

Conclusion: Alcohol intake and tobacco smoking are independently associated with increased risk of Dupuytren's disease, and the combination of the two conveys a very large risk.

MeSH terms

  • Adult
  • Age Distribution
  • Aged
  • Aged, 80 and over
  • Alcohol Drinking / adverse effects*
  • Denmark / epidemiology
  • Dose-Response Relationship, Drug
  • Dupuytren Contracture / epidemiology
  • Dupuytren Contracture / etiology*
  • Epidemiologic Methods
  • Ethanol / administration & dosage
  • Female
  • Humans
  • Life Style
  • Male
  • Middle Aged
  • Sex Distribution
  • Smoking / adverse effects*


  • Ethanol