5-(Aminomethyl)-3-aryldihydrofuran-2(3H)-ones, a New Class of Monoamine oxidase-B Inactivators

J Med Chem. 1992 Mar 6;35(5):885-9. doi: 10.1021/jm00083a012.

Abstract

Both cis- and trans-5-(aminomethyl)-3-aryldihydrofuran-2(3H)-one hydrochloride salts (9 and 10) were synthesized efficiently in a 5-step sequence from arylacetic acids. Both compounds were found to be irreversible inactivators of monoamine oxidase B. These compounds constitute the first members of a new class of monoamine oxidase inactivators.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cattle
  • Furans / chemical synthesis*
  • Furans / pharmacology
  • Kinetics
  • Lactones / chemical synthesis*
  • Lactones / pharmacology
  • Liver / enzymology
  • Methylamines / chemical synthesis
  • Methylamines / pharmacology
  • Molecular Structure
  • Monoamine Oxidase Inhibitors / chemical synthesis*
  • Monoamine Oxidase Inhibitors / pharmacology
  • Stereoisomerism

Substances

  • Furans
  • Lactones
  • Methylamines
  • Monoamine Oxidase Inhibitors