Signaling in myxobacteria

Annu Rev Microbiol. 2004;58:75-98. doi: 10.1146/annurev.micro.58.030603.123620.

Abstract

Myxobacteria use soluble and cell-contact signals during their starvation-induced formation of fruiting bodies. These signals coordinate developmental gene expression with the cell movements that build fruiting bodies. Early in development, the quorum-sensing A-signal in Myxococcus xanthus helps to assess starvation and induce the first stage of aggregation. Later, the morphogenetic C-signal helps to pattern cell movement and shape the fruiting body. C-signal is a 17-kDa cell surface protein that signals by contact between the ends of two cells. The number of C-signal molecules per cell rises 100-fold from the beginning of fruiting body development to the end, when spores are formed. Traveling waves, streams, and sporulation have increasing thresholds for C-signal activity, and this progression ensures that spores form inside fruiting bodies.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Myxococcus xanthus / genetics
  • Myxococcus xanthus / growth & development
  • Myxococcus xanthus / physiology*
  • Signal Transduction / genetics
  • Signal Transduction / physiology*
  • Spores, Bacterial / physiology
  • Stigmatella aurantiaca / genetics
  • Stigmatella aurantiaca / growth & development
  • Stigmatella aurantiaca / physiology*