Bacterial flagellins: mediators of pathogenicity and host immune responses in mucosa

Trends Microbiol. 2004 Nov;12(11):509-17. doi: 10.1016/j.tim.2004.09.002.

Abstract

Flagella contribute to the virulence of pathogenic bacteria through chemotaxis, adhesion to and invasion of host surfaces. Flagellin is the structural protein that forms the major portion of flagellar filaments. Thus, flagellin consists of a conserved domain that is widespread in bacterial species and is dedicated to filament polymerization. Conversely, mammalian hosts detect the conserved domain on flagellin monomers through Toll-like receptor (TLR) 5, which triggers proinflammatory and adaptive immune responses. This review describes the relationships among flagellin molecular structure, bacterial virulence and host defenses, with special emphasis on mucosal tissues.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Bacteria / immunology*
  • Bacteria / pathogenicity*
  • Bacterial Infections / immunology
  • Bacterial Infections / microbiology*
  • Bacterial Physiological Phenomena
  • Bacterial Proteins / immunology*
  • Bacterial Proteins / physiology*
  • Flagellin*
  • Humans
  • Mucous Membrane / immunology
  • Mucous Membrane / microbiology
  • Virulence Factors / immunology*
  • Virulence Factors / physiology*

Substances

  • Bacterial Proteins
  • Virulence Factors
  • Flagellin