Interleukin-1B gene promoter variants are associated with an increased risk of gastric cancer in a Chinese population

Cancer Lett. 2004 Nov 25;215(2):191-8. doi: 10.1016/j.canlet.2004.07.012.


Studies suggest that IL-1beta (encoded by IL-1B gene) is a pro-inflammatory cytokine and potent inhibitor of gastric acid secretion, which is proposed as a key determinant in gastric carcinogenesis. Two potentially functional polymorphisms (C-31T and T-511C) in the IL-1B promoter were suggested to be correlated with alteration of Helicobacter pylori infection and IL-1beta expression and therefore may be associated with risk of gastric cancer. To test the hypothesis that these two polymorphisms are associated with gastric cancer risk, we performed a case-control study of 280 histologically confirmed gastric cancer patients and 258 age, sex frequency-matched cancer-free controls in a Chinese population. Multivariate logistic regression analyses revealed that the risks (adjusted odds ratio [OR] and 95% confidence interval [CI]) associated with the IL-1B variant genotypes were 1.64 (95% CI, 1.01-2.66) for -31TT and 1.52 (95% CI, 0.91-2.54) for -511CC, respectively, compared with their wild-type homozygotes. The risks were significantly more evident in individuals with H. pylori infection (adjusted OR, 2.14; 95% CI, 1.13-4.06 for -31TT; adjusted OR, 2.00; 95% CI, 1.02-3.89 for -511CC), which was consistent with the biological effects of IL-1beta. When we used the haplotype analyses and assumed the IL-1B -31T and -511C as risk alleles, no synergistic effect was found between these two loci. These findings indicate that these two IL-1B promoter variants may contribute to the risk of developing gastric cancer in the Chinese population, especially in individuals with H. pylori infection.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Asian People
  • Case-Control Studies
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease
  • Helicobacter Infections / complications
  • Helicobacter pylori
  • Humans
  • Interleukin-1 / genetics*
  • Interleukin-1beta
  • Male
  • Middle Aged
  • Peptide Fragments / genetics*
  • Polymorphism, Genetic*
  • Promoter Regions, Genetic
  • Risk
  • Stomach Neoplasms / genetics*


  • Interleukin-1
  • Interleukin-1beta
  • Peptide Fragments
  • interleukin-1beta (163-171)