Re-structuring the host cell: up close with Salmonella's molecular machinery

Microbes Infect. 2004 Nov;6(13):1205-11. doi: 10.1016/j.micinf.2004.08.001.

Abstract

A common theme in bacterial disease is the manipulation of the eukaryotic cytoskeleton by pathogenic factors. Understanding how virulence factors operate to achieve these alterations is a growing and important research effort. This review focuses on several virulence factors from the pathogen Salmonella, and considers the contributions of structural biology to our appreciation of bacterial modulation of cytoskeletal dynamics.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Bacterial Proteins / chemistry
  • Bacterial Proteins / metabolism*
  • Cytoskeleton / metabolism
  • Humans
  • Models, Molecular
  • Protein Transport
  • Salmonella / metabolism
  • Salmonella / pathogenicity*
  • Virulence Factors / chemistry
  • Virulence Factors / metabolism*
  • rho GTP-Binding Proteins / chemistry
  • rho GTP-Binding Proteins / metabolism

Substances

  • Bacterial Proteins
  • Virulence Factors
  • rho GTP-Binding Proteins