Extract of Kurosu, a vinegar from unpolished rice, inhibits azoxymethane-induced colon carcinogenesis in male F344 rats

Nutr Cancer. 2004;49(2):170-3. doi: 10.1207/s15327914nc4902_8.


The modifying effects of administering an ethyl acetate extract of Kurosu (EK), a vinegar made from unpolished rice, in drinking water on the development of azoxymethane (AOM)-induced colon carcinogenesis were investigated in male F344 rats. Animals were given 2 weekly subcutaneous injections of AOM (20 mg/kg body weight). They also received drinking water containing 0%, 0.05%, or 0.1% EK for 35 wk, starting 1 wk after the last dosing of AOM. EK administration significantly inhibited the incidence and multiplicity of colon adenocarcinoma (P < 0.05), compared with those in the AOM alone group. These findings suggest that EK may be effective for inhibiting colon carcinogenesis.

MeSH terms

  • Acetic Acid / pharmacology*
  • Animals
  • Anticarcinogenic Agents / pharmacology*
  • Azoxymethane / toxicity
  • Carcinogens / toxicity
  • Colonic Neoplasms / chemically induced
  • Colonic Neoplasms / epidemiology
  • Colonic Neoplasms / prevention & control*
  • Dose-Response Relationship, Drug
  • Drinking
  • Male
  • Oryza / chemistry*
  • Plant Extracts / pharmacology*
  • Random Allocation
  • Rats
  • Rats, Inbred F344


  • Anticarcinogenic Agents
  • Carcinogens
  • Plant Extracts
  • Azoxymethane
  • Acetic Acid