Effect of Solanum trilobatum against carbon tetrachloride induced hepatic damage in albino rats

Indian J Med Res. 2004 Sep;120(3):194-8.

Abstract

Background & objectives: Many hepatoprotective herbal preparations have been recommended in alternative systems of medicine for the treatment of hepatic disorders. No systematic study has been done on protective efficacy of Solanum trilobatum to treat hepatic diseases. Protective action of Solanum trilobatum extract (STE) was evaluated by us in an animal model of hepatotoxicity induced by carbon tetrachloride (CCl4).

Methods: Wistar albino rats were divided into five groups. Group I was normal control group; Group II, the hepatotoxic group was given CCl4; Groups III-V received different doses of plant extract with CCl(4). Liver marker enzymes were assayed in serum and antioxidant status was assessed in liver tissue.

Results: Levels of marker enzymes such as alanine transminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), and lactate dehydrogenase (LDH) were increased significantly in CCl4 treated rats (group II). STE brought about a significant decrease in the activities of all these enzymes. Lipid peroxidation (LP) was increased significant in liver tissue in the CCl4 treated rats (group II) while the activities of glutathione peroxidase (GPx), catalase (CAT) and superoxide dismutase (SOD) were decreased. STE treatment led to the recovery of these levels to near normal.

Interpretation & conclusion: The present observations suggested that the treatment with S. trilobatum extract enhance the recovery from CCl4 induced hepatic damage due to its antioxidant and hepatoprotective property.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alanine Transaminase / blood
  • Alkaline Phosphatase / blood
  • Animals
  • Antioxidants / therapeutic use*
  • Aspartate Aminotransferases / blood
  • Carbon Tetrachloride / toxicity*
  • Chemical and Drug Induced Liver Injury*
  • Glutathione Peroxidase / metabolism
  • L-Lactate Dehydrogenase / blood
  • Lipid Peroxidation / drug effects
  • Liver Diseases / drug therapy*
  • Plant Extracts / therapeutic use
  • Rats
  • Rats, Wistar
  • Solanum / chemistry*
  • Superoxide Dismutase / metabolism

Substances

  • Antioxidants
  • Plant Extracts
  • Carbon Tetrachloride
  • L-Lactate Dehydrogenase
  • Glutathione Peroxidase
  • Superoxide Dismutase
  • Aspartate Aminotransferases
  • Alanine Transaminase
  • Alkaline Phosphatase