The interplay between Src family kinases and receptor tyrosine kinases

Oncogene. 2004 Oct 18;23(48):7957-68. doi: 10.1038/sj.onc.1208079.


Src family tyrosine kinases (SFKs) are involved in a diverse array of physiological processes, as highlighted in this review. An overview of how SFKs interact with, and participate in signaling from, receptor tyrosine kinases (RTKs) is discussed. And also, how SFKs are activated by RTKs, and how SFKs, in turn, can activate RTKs, as well as how SFKs can promote signaling from growth factor receptors in a number of ways including participation in signaling pathways required for DNA synthesis, control of receptor turnover, actin cytoskeleton rearrangements and motility, and survival are discussed.

Publication types

  • Review

MeSH terms

  • Animals
  • DNA / biosynthesis
  • Gene Expression Regulation / physiology*
  • Humans
  • Mitosis / physiology
  • Models, Biological
  • Proto-Oncogene Proteins c-myc / metabolism
  • Receptor Protein-Tyrosine Kinases / metabolism*
  • Tumor Suppressor Protein p53 / metabolism
  • src-Family Kinases / metabolism*


  • Proto-Oncogene Proteins c-myc
  • Tumor Suppressor Protein p53
  • DNA
  • Receptor Protein-Tyrosine Kinases
  • src-Family Kinases