The involvement of endothelial progenitor cells in tumor angiogenesis

J Cell Mol Med. Jul-Sep 2004;8(3):294-300. doi: 10.1111/j.1582-4934.2004.tb00319.x.


Endothelial progenitor cells (EPCs) have been isolated from peripheral blood CD34, VEGFR-2, or AC 133 (CD133) antigen-positive cells, which may home to site of neovascularization and differentiate into endothelial cells in situ. Endothelial cells contribute to tumor angiogenesis, and can originate from sprouting or co-option of neighbouring pre-existing vessels. Emerging evidence indicate that bone marrow-derived circulating EPCs can contribute to tumor angiogenesis and growth of certain tumors. This review article will summarize the literature data concerning this new role played by EPCs in tumor angiogenesis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • AC133 Antigen
  • Animals
  • Antigens, CD / metabolism
  • Antigens, CD34 / metabolism
  • Cell Differentiation
  • Cell Lineage
  • Endothelial Cells / pathology*
  • Endothelium, Vascular / pathology
  • Glycoproteins / metabolism
  • Hematopoietic Stem Cells / pathology
  • Humans
  • Neoplasms / blood supply*
  • Neovascularization, Pathologic / pathology*
  • Peptides / metabolism
  • Stem Cells / pathology*
  • Vascular Endothelial Growth Factor Receptor-2 / metabolism


  • AC133 Antigen
  • Antigens, CD
  • Antigens, CD34
  • Glycoproteins
  • PROM1 protein, human
  • Peptides
  • Vascular Endothelial Growth Factor Receptor-2