Lack of response to isotretinoin in annular elastolytic giant cell granuloma

J Dermatol. 2004 Aug;31(8):678-81. doi: 10.1111/j.1346-8138.2004.tb00576.x.


Annular elastolytic giant cell granuloma is a rare disease characterized by annular configurated lesions with typical histopathologic findings. We report a case of annular elastolytic giant cell granuloma in a 50-year-old male patient. Treatment modalities for this disease are limited and mostly unsatisfactory, although isotretinoin was found to be effective in a single case. However, systemic isotretinoin treatment of 12 weeks' duration was of no benefit in the presented case.

Publication types

  • Case Reports

MeSH terms

  • Administration, Oral
  • Diagnosis, Differential
  • Granuloma, Giant Cell / diagnosis*
  • Granuloma, Giant Cell / drug therapy*
  • Granuloma, Giant Cell / pathology
  • Humans
  • Isotretinoin / administration & dosage
  • Isotretinoin / therapeutic use*
  • Keratolytic Agents / administration & dosage
  • Keratolytic Agents / therapeutic use*
  • Male
  • Middle Aged
  • Neck
  • Skin Neoplasms / diagnosis*
  • Skin Neoplasms / drug therapy*
  • Skin Neoplasms / pathology
  • Treatment Failure


  • Keratolytic Agents
  • Isotretinoin