Mechanisms of elongation on the ribosome: dynamics of a macromolecular machine

W Wintermeyer; F Peske; M Beringer; K B Gromadski; A Savelsbergh; M V Rodnina

doi:10.1042/BST0320733

Mechanisms of elongation on the ribosome: dynamics of a macromolecular machine

Biochem Soc Trans. 2004 Nov;32(Pt 5):733-7. doi: 10.1042/BST0320733.

Authors

W Wintermeyer¹, F Peske, M Beringer, K B Gromadski, A Savelsbergh, M V Rodnina

Affiliation

¹ Institute of Molecular Biology, University of Witten/Herdecke, Stockumer Str. 10, 58448 Witten, Germany. winterme@uni-wh.de

PMID: 15494001
DOI: 10.1042/BST0320733

Abstract

Protein synthesis in the cell is performed on ribosomes, large ribonucleoprotein particles, which in bacteria consist of three RNA molecules and over 50 proteins. This review summarizes recent progress in understanding the mechanisms of the elongation phase of protein synthesis. Results from rapid kinetic analysis of elongation reactions are discussed in the light of recent structural data.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Binding Sites
Codon
Entropy
Hydrolysis
Kinetics
Macromolecular Substances / chemistry*
Models, Biological
Peptides / chemistry
Protein Conformation
Protein Transport
Proteins / chemistry
RNA, Transfer / chemistry
Ribosomes / chemistry*
Ribosomes / metabolism

Substances

Codon
Macromolecular Substances
Peptides
Proteins
RNA, Transfer