Crumbs homologue 1 in polarity and blindness

Biochem Soc Trans. 2004 Nov;32(Pt 5):828-30. doi: 10.1042/BST0320828.

Abstract

Several retinal dystrophies, including retinitis pigmentosa type 12 and Leber congenital amaurosis, are caused by a large variety of mutations in the CRB1 (Crumbs homologue 1) gene. This discovery led to an increased focus on the function of CRB1 and the Drosophila homologue Crumbs. In the present study, we review the current knowledge on Crumbs and its vertebrate homologues, their function in cell polarity and their pathogenicity in retinal degeneration.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Drosophila
  • Drosophila Proteins / metabolism
  • Drosophila Proteins / physiology*
  • Eye Proteins / metabolism
  • Eye Proteins / physiology*
  • Humans
  • Membrane Proteins / metabolism
  • Membrane Proteins / physiology*
  • Models, Biological
  • Molecular Sequence Data
  • Mutation
  • Nerve Tissue Proteins / metabolism
  • Nerve Tissue Proteins / physiology*
  • Protein Structure, Tertiary
  • Retinal Degeneration / genetics*
  • Sequence Homology, Amino Acid

Substances

  • CRB1 protein, human
  • Drosophila Proteins
  • Eye Proteins
  • Membrane Proteins
  • Nerve Tissue Proteins
  • crb protein, Drosophila