Ann Diagn Pathol. 2004 Oct;8(5):290-4. doi: 10.1016/j.anndiagpath.2004.07.006.


Pituicytoma is a rare, low-grade neoplasm that originates in the neurohypophysis of the pituitary gland. We report the clinicopathologic features of a pituicytoma arising in a 52-year-old man who presented with a mass and panhypopituitarism, clinically suggestive of a pituitary adenoma. The tumor was marked by a proliferation of elongated cells arranged in bundles and interlacing fascicles. The tumor demonstrated positive staining with S-100 protein and glial fibrillary acid protein antibodies. The tumor did not stain with antibodies to cytokeratin, synaptophysin, chromogranin, anterior pituitary hormones, or p53. An MIB-1 labeling index of 1.1% was observed. The tumor was subtotally resected and recurred 11 months after the initial surgery. The literature on this rare tumor will be reviewed and differential diagnosis discussed.

Publication types

  • Case Reports

MeSH terms

  • Biomarkers, Tumor / metabolism
  • Combined Modality Therapy
  • Glial Fibrillary Acidic Protein / metabolism
  • Glioma / metabolism
  • Glioma / pathology*
  • Glioma / therapy
  • Humans
  • Immunoenzyme Techniques
  • Ki-67 Antigen / metabolism
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local
  • Pituitary Gland, Posterior / metabolism
  • Pituitary Gland, Posterior / pathology*
  • Pituitary Gland, Posterior / surgery
  • Pituitary Neoplasms / metabolism
  • Pituitary Neoplasms / pathology*
  • Pituitary Neoplasms / therapy
  • Radiotherapy, Adjuvant
  • S100 Proteins / metabolism


  • Biomarkers, Tumor
  • Glial Fibrillary Acidic Protein
  • Ki-67 Antigen
  • S100 Proteins