Synthesis of the tubuvaline-tubuphenylalanine (Tuv-Tup) fragment of tubulysin

Org Lett. 2004 Oct 28;6(22):4057-60. doi: 10.1021/ol048252i.

Abstract

[structure: see text] Advanced intermediates and analogues of tubulysins were prepared in a convergent strategy.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / pharmacology
  • Molecular Structure
  • Oligopeptides / chemical synthesis*
  • Oligopeptides / pharmacology
  • Peptide Fragments / chemical synthesis
  • Phenylalanine / analogs & derivatives
  • Phenylalanine / chemistry*
  • Stereoisomerism
  • Valine / analogs & derivatives
  • Valine / chemistry*

Substances

  • Antineoplastic Agents
  • Oligopeptides
  • Peptide Fragments
  • tubulysin D
  • Phenylalanine
  • Valine