Agreement of carbon dioxide levels measured by arterial, transcutaneous and end tidal methods in preterm infants < or = 28 weeks gestation

J Perinatol. 2005 Jan;25(1):26-9. doi: 10.1038/


Objective: To assess the agreement of transcutaneous carbon dioxide (TcPCO(2)) and end tidal carbon dioxide (PetCO(2)) with arterial carbon dioxide (PaCO(2)) values in infants < 28 weeks gestational age.

Study design: In all, 27 ventilated preterm infants were prospectively studied. PaCO(2) was compared with TcPCO(2) and PetCO(2) measured at three similar time points within first 24 hours after birth.

Results: The Intraclass correlation coefficients for TcPCO(2) and PaCO(2) were 0.45, 0.73 and 0.53; and for PetCO(2) and PaCO(2) were 0.61, 0.56 and 0.57 at 4, 12 and 24 hours after birth, respectively.

Conclusion: A moderate agreement with a wide variation in individual values was observed between noninvasive methods and PaCO(2) in preterm infants in the first 24 hours. Noninvasive monitoring methods cannot be substituted for PaCO(2) analyses in preterm infants during this critical period.

MeSH terms

  • Age Factors
  • Blood Gas Monitoring, Transcutaneous*
  • Blood Pressure
  • Breath Tests*
  • Carbon Dioxide / blood*
  • Catheters, Indwelling
  • Female
  • Humans
  • Infant, Newborn
  • Infant, Premature
  • Male
  • Observer Variation
  • Prospective Studies
  • Pulmonary Ventilation
  • Respiration, Artificial
  • Respiratory Distress Syndrome, Newborn / blood*
  • Respiratory Distress Syndrome, Newborn / therapy


  • Carbon Dioxide