Hypovitaminosis D-induced pain

Nutr Rev. 2004 Sep;62(9):354-9. doi: 10.1111/j.1753-4887.2004.tb00061.x.


Vitamin D deficiency is a problem of considerable magnitude that has reemerged as a major public health issue in the United States and several other developed countries. Vitamin D plays a crucial role in calcium homeostasis in the body. Hypovitaminosis D leads to osteomalacia and increased risk of fractures, especially in the elderly. Preliminary research suggests that vitamin D can prevent certain types of cancer and autoimmune diseases. A recent large study has shown the association between severe hypovitaminosis D and persistent, non-specific musculoskeletal pain, further suggesting that patients with no apparent cause of pain should be assessed and possibly treated for vitamin D deficiency.

Publication types

  • Review

MeSH terms

  • Calcium / metabolism*
  • Developing Countries
  • Fractures, Bone / etiology
  • Humans
  • Osteomalacia / etiology
  • Pain / etiology*
  • Vitamin D / blood*
  • Vitamin D Deficiency / metabolism
  • Vitamin D Deficiency / physiopathology*


  • Vitamin D
  • Calcium