A novel antimicrobial indolizinium alkaloid from Aniba panurensis

J Nat Prod. 2004 Oct;67(10):1732-5. doi: 10.1021/np040114e.

Abstract

Activity-guided fractionation of an Aniba panurensis organic solvent extract has led to the isolation of the novel alkaloid 6,8-didec-(1Z)-enyl-5,7-dimethyl-2,3-dihydro-1H-indolizinium, as the trifluoroacetic acid salt (1). Its structure was determined by NMR and mass spectrometry. Bioassays performed in vitro demonstrated toxicity of compound 1 to a drug-resistant strain of Candida albicans.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antifungal Agents / chemistry
  • Antifungal Agents / isolation & purification*
  • Antifungal Agents / pharmacology
  • Candida albicans / drug effects*
  • Cryptococcus neoformans / drug effects
  • Enterococcus faecium / drug effects
  • Fluoroacetates
  • Guyana
  • Indole Alkaloids / chemistry
  • Indole Alkaloids / isolation & purification*
  • Indole Alkaloids / pharmacology
  • Lauraceae / chemistry*
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Plants, Medicinal / chemistry*
  • Staphylococcus aureus / drug effects

Substances

  • 6,8-didec-(1Z)-enyl-5,7-dimethyl-2,3-dihydro-1H-indolizinium, trifluoroacetic acid salt
  • Antifungal Agents
  • Fluoroacetates
  • Indole Alkaloids