Damage signaling: RecQ sends an SOS to you

Curr Biol. 2004 Oct 26;14(20):R895-7. doi: 10.1016/j.cub.2004.09.073.

Abstract

The DNA helicase RecQ is required for proper induction of the SOS response to replication stress in Escherichia coli. Unwinding of stalled replication forks by RecQ family helicases in bacteria, and possibly in eukaryotes, may provide a means of damage signaling and recovering stalled replication forks.

Publication types

  • Review

MeSH terms

  • Adenosine Triphosphatases / metabolism*
  • Adenosine Triphosphatases / physiology
  • DNA Helicases / metabolism*
  • DNA Helicases / physiology
  • DNA Replication / physiology
  • Escherichia coli
  • Models, Genetic*
  • RecQ Helicases
  • Recombination, Genetic / physiology*
  • SOS Response, Genetics / physiology*
  • Signal Transduction / physiology*

Substances

  • Adenosine Triphosphatases
  • RecQ protein, E coli
  • DNA Helicases
  • RecQ Helicases