The ENCODE (ENCyclopedia Of DNA Elements) Project

Science. 2004 Oct 22;306(5696):636-40. doi: 10.1126/science.1105136.


The ENCyclopedia Of DNA Elements (ENCODE) Project aims to identify all functional elements in the human genome sequence. The pilot phase of the Project is focused on a specified 30 megabases (approximately 1%) of the human genome sequence and is organized as an international consortium of computational and laboratory-based scientists working to develop and apply high-throughput approaches for detecting all sequence elements that confer biological function. The results of this pilot phase will guide future efforts to analyze the entire human genome.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Access to Information
  • Animals
  • Computational Biology*
  • Conserved Sequence
  • Databases, Nucleic Acid
  • Evolution, Molecular
  • Genome, Human*
  • Genomics*
  • Humans
  • Information Dissemination
  • Internet
  • National Institutes of Health (U.S.)
  • Pilot Projects
  • Proteins / genetics
  • Publishing
  • Regulatory Sequences, Nucleic Acid
  • Sequence Analysis, DNA
  • United States


  • Proteins