Systems biology and new technologies enable predictive and preventative medicine

Science. 2004 Oct 22;306(5696):640-3. doi: 10.1126/science.1104635.


Systems approaches to disease are grounded in the idea that disease-perturbed protein and gene regulatory networks differ from their normal counterparts; we have been pursuing the possibility that these differences may be reflected by multiparameter measurements of the blood. Such concepts are transforming current diagnostic and therapeutic approaches to medicine and, together with new technologies, will enable a predictive and preventive medicine that will lead to personalized medicine.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Biomarkers / blood
  • Computational Biology*
  • Databases, Nucleic Acid
  • Diagnosis
  • Disease Progression
  • Disease*
  • Forecasting
  • Gene Expression
  • Gene Expression Profiling
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Male
  • Microfluidics
  • Nanotechnology
  • Preventive Medicine*
  • Prostate / physiology
  • Prostatic Neoplasms / genetics
  • Prostatic Neoplasms / metabolism
  • Systems Analysis
  • Systems Theory
  • Therapeutics


  • Biomarkers