Effect of extracts from Rhodiola rosea and Rhodiola crenulata (Crassulaceae) roots on ATP content in mitochondria of skeletal muscles

Bull Exp Biol Med. 2003 Dec;136(6):585-7. doi: 10.1023/b:bebm.0000020211.24779.15.


We studied the effects of oral treatment with extracts from Rhodiola rosea (50 mg/kg) and Rhodiola crenulata (50 mg/kg) roots on the duration of exhaustive swimming and ATP content in mitochondria of skeletal muscles in rats. Treatment with R. rosea extract significantly (by 24.6%) prolonged the duration of exhaustive swimming in comparison with control rats and rats treated with R. crenullata. R. rosea extract activated the synthesis or resynthesis of ATP in mitochondria and stimulated reparative energy processes after intense exercise. Experiments proved different pharmacological characteristics of R. rosea and R. crenulata: R. rosea is most effective for improving physical working capacity.

Publication types

  • Comparative Study

MeSH terms

  • Adenosine Triphosphate / analysis*
  • Adenosine Triphosphate / biosynthesis
  • Animals
  • Mitochondria / metabolism*
  • Muscle, Skeletal / cytology
  • Muscle, Skeletal / drug effects*
  • Physical Endurance / drug effects
  • Plant Extracts / pharmacology*
  • Plant Roots / chemistry*
  • Rats
  • Rats, Sprague-Dawley
  • Rhodiola / chemistry*
  • Swimming


  • Plant Extracts
  • Adenosine Triphosphate