High expression of endothelial cell nitric oxide synthase in peritumoral microvessels predicts increased disease-free survival in colorectal cancer

Cancer Lett. 2004 Dec 8;216(1):109-14. doi: 10.1016/j.canlet.2004.05.025.


We have previously shown that a high frequency of microvessels expressing endothelial cell nitric oxide synthase (ecNOS) in the area surrounding the primary tumor (peritumoral ecNOS-expressing microvessel density: PEMVD) is a favorable prognostic indicator in breast cancer. Studies of a retrospective material of 186 colorectal tumors (Duke's stage B) now show that PEMVD is a significant and independent prognostic indicator for disease-free survival also in these patients. These data reinforce our hypothesis that a high level of expression of ecNOS in microvessels in the tumor-adjacent area protects against tumor metastasis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Colorectal Neoplasms / blood supply
  • Colorectal Neoplasms / genetics*
  • Colorectal Neoplasms / pathology*
  • Disease-Free Survival
  • Female
  • Humans
  • Immunohistochemistry
  • Male
  • Microcirculation
  • Middle Aged
  • Neoplasm Metastasis
  • Neovascularization, Pathologic*
  • Nitric Oxide Synthase / biosynthesis*
  • Prognosis
  • Retrospective Studies


  • Nitric Oxide Synthase