Hypoxic-ischemic brain injury in the term infant-current concepts

Early Hum Dev. 2004 Nov;80(2):125-41. doi: 10.1016/j.earlhumdev.2004.06.003.


An enhanced understanding of the cellular characteristics contributing to ongoing brain injury following intrapartum hypoxia-ischemia has resulted in the implementation of targeted neuroprotective strategies in the newborn period. This review briefly covers the pathogenesis of hypoxic-ischemic injury with an emphasis on reperfusion injury; the role of magnetic resonance imaging in the detection of such injury, and focuses on potential strategies both supportive and neuroprotective to prevent ongoing injury with a specific emphasis on modest hypothermia.

Publication types

  • Review

MeSH terms

  • Brain / pathology
  • Cerebral Palsy / etiology
  • Humans
  • Hypothermia, Induced
  • Hypoxia-Ischemia, Brain / complications*
  • Hypoxia-Ischemia, Brain / pathology
  • Hypoxia-Ischemia, Brain / therapy*
  • Infant, Newborn
  • Magnetic Resonance Imaging
  • Neuroprotective Agents / therapeutic use
  • Reperfusion Injury / etiology*
  • Reperfusion Injury / pathology
  • Reperfusion Injury / therapy*


  • Neuroprotective Agents