Aurora kinases in spindle assembly and chromosome segregation

Exp Cell Res. 2004 Nov 15;301(1):60-7. doi: 10.1016/j.yexcr.2004.08.016.

Abstract

The Aurora kinase family consists of three members, Aurora A, B, and C. The Aurora A and B kinases have emerged as essential regulators of cell division. While Aurora A kinase is implicated in regulating mitotic entry, centrosome maturation, and spindle assembly, Aurora B is required for correct chromosome segregation and cytokinesis. In this review, we summarize the roles of Aurora A and B in spindle assembly and chromosome segregation.

Publication types

  • Review

MeSH terms

  • Animals
  • Aurora Kinase B
  • Aurora Kinases
  • Chromosome Segregation*
  • Cytokinesis / physiology
  • Humans
  • Mitosis / physiology
  • Protein-Serine-Threonine Kinases / physiology*
  • Spindle Apparatus / physiology

Substances

  • AURKB protein, human
  • Aurora Kinase B
  • Aurora Kinases
  • Protein-Serine-Threonine Kinases