Adrenomedullin receptors: pharmacological features and possible pathophysiological roles

Kenji Kuwasako; Yuan-Ning Cao; Yasuko Nagoshi; Kazuo Kitamura; Tanenao Eto

doi:10.1016/j.peptides.2004.06.002

Adrenomedullin receptors: pharmacological features and possible pathophysiological roles

Peptides. 2004 Nov;25(11):2003-12. doi: 10.1016/j.peptides.2004.06.002.

Authors

Kenji Kuwasako¹, Yuan-Ning Cao, Yasuko Nagoshi, Kazuo Kitamura, Tanenao Eto

Affiliation

¹ First Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan. kuwasako@fc.miyazaki-med.ac.jp

PMID: 15501534
DOI: 10.1016/j.peptides.2004.06.002

Abstract

Three receptor activity modifying proteins (RAMPs) chaperone calcitonin-like receptor (CLR) to the cell surface. RAMP2 enables CLR to form an adrenomedullin (AM)-specific receptor that is sensitive to AM-(22-52) (AM(1) receptor). RAMP3 enables CLR to form an AM receptor sensitive to both calcitonin gene-related peptide (CGRP)-(8-37) and AM-(22-52) (AM(2) receptor), though rat and mouse AM(2) receptors show a clear preference for CGRP alpha-(8-37) over AM-(22-52). RAMP1 enables CRL to form the CGRP-(8-37)-sensitive CGRP(1) receptor, which can also be activated by higher concentrations of AM. Here we review the available information on the pharmacological features and possible pathophysiological roles of the aforementioned AM receptors.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Forecasting
Humans
Protein Binding
RNA, Messenger / metabolism
Receptors, Adrenomedullin
Receptors, Calcitonin / metabolism*
Receptors, Peptide / metabolism*

Substances

RNA, Messenger
Receptors, Adrenomedullin
Receptors, Calcitonin
Receptors, Peptide