The pharmacology of CGRP-responsive receptors in cultured and transfected cells

Peptides. 2004 Nov;25(11):2019-26. doi: 10.1016/j.peptides.2004.06.007.


Historically, CGRP receptors have been classified as CGRP(1) or CGRP(2) subtypes, chiefly depending on their affinity for the antagonist CGRP(8-37). It has been shown that the complex between calcitonin receptor-like receptor (CRLR or CL) and receptor activity modifying protein (RAMP) 1 provides a molecular correlate for the CGRP(1) receptor; however, this does not explain the range of affinities seen for CGRP(8-37) in isolated tissues. It is suggested that these may largely be explained by a combination of methodological factors and CGRP-responsive receptors generated by CL and RAMP2 or RAMP3 and complexes of RAMPs with the calcitonin receptor.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Calcitonin Gene-Related Peptide*
  • Cell Line
  • Humans
  • Receptors, Calcitonin / metabolism*
  • Receptors, Calcitonin Gene-Related Peptide / metabolism*
  • Receptors, Peptide / metabolism*
  • Transfection*


  • Receptors, Calcitonin
  • Receptors, Calcitonin Gene-Related Peptide
  • Receptors, Peptide
  • Calcitonin Gene-Related Peptide