Optimal and effective oral dose of taurine to prolong exercise performance in rat

Amino Acids. 2004 Dec;27(3-4):291-8. doi: 10.1007/s00726-004-0133-1. Epub 2004 Oct 22.


The aim of this study was to determine the effective and optimum dose of taurine for exercise performance and to maintain tissue taurine concentration. Rats received a respective daily dose of 0, 20, 100, and 500 mg/kg body weight of taurine (EC and ET-1, -2, -3 groups, respectively) for two weeks, and then, were subjected to treadmill until exhaustion. The running time to exhaustion was significantly prolonged by 25% and 50% in the ET-2 and -3 groups, respectively, compared to that in the EC group accompanied with maintenance of taurine tissue concentrations. Furthermore, the oxidative glutathione per total glutathione ratio in tissues was inhibited in the ET-2 and -3 groups whereas it was higher in the EC group than in both the no exercise and taurine-administered groups. Therefore the effective and optimal doses of oral taurine administration for two weeks on a transient exercise performance were between 100 and 500 mg/kg/day.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Animals
  • Body Weight / drug effects
  • Dose-Response Relationship, Drug
  • Glutathione / blood
  • Glutathione / metabolism
  • Glutathione Disulfide / blood
  • Glutathione Disulfide / metabolism
  • Lipid Peroxides / blood
  • Lipid Peroxides / metabolism
  • Male
  • Organ Size / drug effects
  • Physical Conditioning, Animal*
  • Physical Endurance
  • Rats
  • Rats, Sprague-Dawley
  • Taurine / administration & dosage*
  • Taurine / blood
  • Taurine / pharmacokinetics
  • Tissue Distribution


  • Lipid Peroxides
  • Taurine
  • Glutathione
  • Glutathione Disulfide