Intraamniotic infection with fusobacteria

Arch Gynecol Obstet. 1992;251(1):1-7. doi: 10.1007/BF02718272.


A literature search produced ten studies in which Fusobacterium was cultured from amniotic fluid in women with preterm labor and intact membranes or with preterm premature rupture of membranes (PROM). Fusobacterium was isolated in 9.9% (9/91) of positive amniotic fluid cultures in women with preterm PROM and in 28.3% (17/60) of positive amniotic fluid cultures in women presenting with preterm labor and intact membranes. Fusobacterium plays a previously unrecognized role in the pathogenesis of premature labor and delivery. Amniotic fluid culture for anaerobes, specifically Fusobacterium, is suggested for all women who present with premature labor and intact membranes and do not respond to tocolytic drugs.

Publication types

  • Review

MeSH terms

  • Amniotic Fluid / microbiology*
  • Female
  • Fetal Membranes, Premature Rupture / etiology
  • Fusobacterium / isolation & purification
  • Fusobacterium Infections / complications
  • Fusobacterium Infections / microbiology*
  • Humans
  • Obstetric Labor, Premature / etiology*
  • Pregnancy
  • Pregnancy Complications, Infectious*