The outcome of pregnancy in the wives of men with familial mediterranean fever treated with colchicine

Semin Arthritis Rheum. 2004 Oct;34(2):549-52. doi: 10.1016/j.semarthrit.2004.07.004.


Objective: To evaluate the outcome of pregnancies of normal women married to men with familial Mediterranean fever (FMF), some of whom took colchicine during the conception with their wives.

Patients and methods: We followed the outcome of pregnancies and deliveries of 60 wives of FMF patients; 53 of the husbands were taking colchicine during that time. As a control group we screened the outcome of pregnancy and delivery from 230 healthy women married to healthy men.

Results: The 60 FMF patients- wives had 222 pregnancies, of which 206 ended in term delivery with 209 live births. Sixteen pregnancies ended in spontaneous abortions (7%). Three of the newborns in the study group were born with congenital malformations. In the control group, of 788 pregnancies, 127 ended in abortions (16%). Six of the newborns were born with congenital malformations. The rate of the late abortions (second trimester) in both groups was comparable.

Conclusions: The results of our study indicates that neither FMF nor colchicine increases the rate of abortions or congenital malformations. Therefore we believe that there is no need to discontinue colchicine treatment in men with FMF before the conception with their wives.

MeSH terms

  • Abortion, Spontaneous / epidemiology*
  • Adult
  • Colchicine / therapeutic use*
  • Familial Mediterranean Fever / drug therapy*
  • Familial Mediterranean Fever / epidemiology
  • Fathers*
  • Female
  • Gout Suppressants / therapeutic use*
  • Humans
  • Male
  • Middle Aged
  • Pregnancy
  • Pregnancy Outcome
  • Risk Factors


  • Gout Suppressants
  • Colchicine