[An experimental study on anti-aging action of Cordyceps extract]

Zhongguo Zhong Yao Za Zhi. 2004 Aug;29(8):773-6.
[Article in Chinese]


Objective: To investigate anti-aging effect and mechanism of Cordyceps extract(CSE) on aged mice induced by D-galactose.

Method: The aged mice were induced by D-galactose. Meanwhile, they were treated with three doses of CSE. Then the ability of learning and memory, the activity of antioxidase in the different tissue, the contents of MDA of brain and liver were measured after 6 weeks.

Result: CSE could significantly increase the ability of learning and memory, improve the activity of SOD of red blood cells, brain and liver, the activity of Na(+) -K(+) -ATPE of brain, the activity of CAT and GSH-Px of blood, and remarkably decrease the activity of MAO of brain and the contents of MDA of brain and liver.

Conclusion: CSE has good anti-aging effects on the aged mice, which is probably due to effects of improving antioxidation and removing free radicals.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging / drug effects*
  • Animals
  • Brain / metabolism
  • Catalase / metabolism
  • Cordyceps / chemistry*
  • Drugs, Chinese Herbal / isolation & purification
  • Drugs, Chinese Herbal / pharmacology*
  • Female
  • Galactose
  • Glutathione Peroxidase / metabolism
  • Lepidoptera / chemistry
  • Liver / metabolism
  • Male
  • Malondialdehyde / metabolism
  • Maze Learning / drug effects
  • Memory Disorders / chemically induced
  • Memory Disorders / metabolism*
  • Mice
  • Mice, Inbred ICR
  • Monoamine Oxidase / metabolism
  • Sodium-Potassium-Exchanging ATPase / metabolism
  • Superoxide Dismutase / metabolism


  • Drugs, Chinese Herbal
  • Malondialdehyde
  • Catalase
  • Glutathione Peroxidase
  • Superoxide Dismutase
  • Monoamine Oxidase
  • Sodium-Potassium-Exchanging ATPase
  • Galactose