Infliximab for the treatment of posterior uveitis with retinal neovascularization in Behçet disease

Eur J Ophthalmol. Sep-Oct 2004;14(5):445-8.

Abstract

Purpose: To report a case of posterior uveitis with retinal neovascularization in a patient with Behçet disease treated with infliximab.

Methods: A 50-year-old man with a history of recurrent relapses of ocular inflammation despite immunosuppressive therapy developed retinal neovascularization near the optic disk. The patient was treated with infliximab and followed up for 12 months.

Results: Retinal neovascularization regressed 8 months after the first anti-tumor necrosis factor (TNF) treatment and with six infusions of infliximab. The ocular inflammation resolved almost completely.

Conclusions: The result suggests that anti-TNF therapy may be effective in the treatment of retinal neovascularization caused by panuveitis in Behçet disease.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antibodies, Monoclonal / therapeutic use*
  • Antirheumatic Agents / therapeutic use*
  • Behcet Syndrome / complications
  • Behcet Syndrome / drug therapy*
  • Fluorescein Angiography
  • Fundus Oculi
  • Humans
  • Infliximab
  • Male
  • Retinal Neovascularization / drug therapy*
  • Retinal Neovascularization / etiology
  • Treatment Outcome
  • Uveitis, Posterior / drug therapy*
  • Uveitis, Posterior / etiology
  • Visual Acuity

Substances

  • Antibodies, Monoclonal
  • Antirheumatic Agents
  • Infliximab