S-laminin expression in adult and developing retinae: a potential cue for photoreceptor morphogenesis

Neuron. 1992 Mar;8(3):399-413. doi: 10.1016/0896-6273(92)90269-j.


The development of the neural retina follows a stereotyped time course that begins with an undifferentiated neuroepithelium populated by multipotential progenitor cells and ends with a highly differentiated tissue containing diverse cell types. The identities of the factors that guide this differentiation have remained elusive; a likely location for such factors, however, is the extracellular environment. Here, we show that the extracellular matrix component s-laminin is present in the neural retina, that s-laminin expression parallels the differentiation of rod photoreceptors, that photoreceptors interact with s-laminin in vitro, and that antibodies to s-laminin profoundly reduce the appearance of cells that express rhodopsin in vitro. These data suggest that s-laminin plays a role in the differentiation of the neural retina and provide evidence that the composition of the extracellular matrix may be an important determinant of retinal differentiation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Blotting, Western
  • Cell Adhesion
  • Cell Differentiation
  • Extracellular Matrix / metabolism
  • Laminin / metabolism*
  • Photoreceptor Cells / cytology*
  • Retina / embryology
  • Retina / metabolism*
  • Skates, Fish


  • Laminin
  • laminin beta2