Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
, 95 (2-3), 169-72

Pharmacological Basis for the Gut Stimulatory Activity of Raphanus Sativus Leaves

Affiliations
Comparative Study

Pharmacological Basis for the Gut Stimulatory Activity of Raphanus Sativus Leaves

Anwarul Hassan Gilani et al. J Ethnopharmacol.

Abstract

The crude extract of Raphanus sativus leaves (Rl.Cr) showed a dose-dependent (0.03-5.0 mg/ml) spasmogenicity in guinea-pig ileum and colon. The effect was insensitive to atropine pre-treatment but was completely abolished by pyrilamine indicating involvement of histaminergic (H(1)) receptors. The contractile effect at high doses (3.0-5.0mg/ml) was followed by relaxation. Rl.Cr also enhanced the transit of charcoal meal in mice at 30-100 mg/kg. The petroleum spirit, chloroform and aqueous fractions all showed histaminergic activity in ileum; aqueous fraction being more potent. The study shows the presence of a histaminergic component(s) along with a weak spasmolytic factor thus providing sound mechanistic basis for the traditional use of the plant in constipation.

Similar articles

See all similar articles

Cited by 5 PubMed Central articles

Publication types

LinkOut - more resources

Feedback